CAM-HERO ABSTRACTS 2024

MOLECULAR EPIDEMIOLOGY OF HUMAN PAPILLOMAVIRUS CIRCULATING IN AFRICAN COUNTRIES ACCORDING TO HIV STATUS, SYSTEMATIC REVUE AND MATA ANALYSIS

Authors:
Larissa Gaelle Moko Fotso, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Michel Carlos Tommo Tchouaket, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Aude Christelle Ka’e, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Ezechiel Ngoufack Jagni Semengue, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Alex Durand Nka, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Samuel Martin Sosso1, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Rachel Kamgaing Simo, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Bouba Yagai, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Collins Chenwi, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Aissatou Abba, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Nadine Fainguem, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Hugues Germain MBA, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Lum Forgwein, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Vincent Mekel, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management
Sando Zacharie, 8. Yaoundé Gynaeco-Obstetric and Paediatric Hospital, Cameroon
Adiogo Dieudonné, 7. Faculty of Medicine and Pharmaceutical Sciences, University of Douala,
Charlotte Charpentier, 9. Service de Virologie, Université Paris Cité, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, F-75018, Paris, France
Valentine Marie Ferrée, 9. Service de Virologie, Université Paris Cité, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, F-75018, Paris, France
Carlo-Federico Perno, University of TOR VERGATA, Rome, Italy
Vittorio Colizzi, University of TOR VERGATA, Rome, Italy
Joseph Fokam, 1. CHANTAL BIYA International Reference Centre For Research on HIV/AIDS prevention and Management

Abstract ID: 325

Event: CAM-HERO 2024

Category: Prevention science

Presenter Name: MOKO FOTSO LARISSA GAELLE

Presenter Preference: Oral

Keywords: Africa, genotyping, high risk human papilloma virus

Introduction: Africa is the continent most affected by human papillomavirus (HPV), the main agent responsible for cervical cancer. The aim of our systematic review was to determine the epidemiology of circulating HPV types from different anatomical sites and the factors associated with the occurrence of cervical cancer in African countries.

Methods: A systematic review and meta-analysis of studies was conducted from January 2013 to December 2023 in Africa on HR-HPV (High Risk- Human Papillomavirus), lesions grading, and determinants, as per diagnostic methods used. Following the search strategy, R software version 3.6.0 was used for the meta-analysis, with p<0.05 considered statistically significant.

Results: 38 studies carried out in Africa were selected, including 24,417 participants (mean age 37). The overall prevalence of HR-HPV was 42.01% in the general population, and 49.8% in HIV-positive populations, versus 21.2% in HIV-negative populations. In HIV-positive individuals, 14 HR-HPV genotypes were identified, the most prevalent being HPV 16 (31.58%), 18 (26.32%), 31 (26.32%) and 33 (23.69%). In contrast, only 12 types of HR-HPV were identified in HIV-negative individuals, the most prevalent genotypes being 16 (13.16%), 33 (15.79%), 35 (10.53%) and 45 (13.16%). According to the risk of CC occurrence, high-grade squamous intraepithelial lesions (HSIL) were 37.5% (9/24) in HIV-positive women versus 12.5% (3/24) in HIV-negative women, OR=3.800 [0.872-16.553], p=0.096. According to the HPV typing methods, On the 38 studies the most commonly used were Roche Linear Array® HPV (31.07%), multiplex PCR (23.7%), Hybrid Capture II (10.5%), AnyplexII28 (5.3%). Several sample types were used, with a predominance of 57.89% (22/38) cervical samples, 23.7% (9/38) biopsies, 7.89% (3/38) oropharyngeal and anal samples, 7.89% (3/38) vaginal samples and 2.63% (1/38) blood samples.

Conclusion: The high genetic diversity of HR-HPV is greater in the HIV-positive population than in the HIV-negative population. This genotypic diversity of HPV means that management depends on HIV serostatus.